• Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization by Li Di, Edward H Kerns

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    • Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization
    • Li Di, Edward H Kerns
    • Page: 580
    • Format: pdf, ePub, mobi, fb2
    • ISBN: 9780128010761
    • Publisher: Elsevier Science

     

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    Free ebook download english dictionary Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization by Li Di, Edward H Kerns 9780128010761

     

    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization. Provides a comprehensive and valuable working handbook for scientists and students in medicinal chemistry Includes expanded coverage of pharmacokinetics fundamentals and effects Contains updates throughout, including the authors’ recent work in the importance of solubility in drug development; new and currently used property methods, with a reduction of seldom-used methods; and exploration of computational modeling methods

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  • The Five Marks of a Man: Finding Your Path to Courageous Manhood. Brian Tome

     

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    • The Five Marks of a Man: Finding Your Path to Courageous Manhood
    • Brian Tome
    • Page: 208
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    • ISBN: 9780801093708
    • Publisher: Baker Publishing Group

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  • Sophia: Princess, Suffragette, Revolutionary by Anita Anand

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    • Sophia: Princess, Suffragette, Revolutionary
    • Anita Anand
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  • Warriors Super Edition: Squirrelflight's Hope by Erin Hunter

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    • Warriors Super Edition: Squirrelflight's Hope
    • Erin Hunter
    • Page: 464
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    • ISBN: 9780062698803
    • Publisher: HarperCollins Publishers

     

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    An epic stand-alone adventure in Erin Hunter’s #1 nationally bestselling Warriors series! Also includes an exclusive ten-page Warriors manga adventure. In this Super Edition, set just after the events of A Vision of Shadows, ThunderClan deputy Squirrelflight is caught between her conscience and her Clan.   Though all five Clans have settled into equally divided territories around the lake, tensions are rising over the new borders. And when a group of rogue cats move in just beyond Clan boundaries, drawing the Clans’ frustration, Squirrelflight must choose between her duty as ThunderClan’s deputy and her desire to do what’s right. Join the legion of fans who have discovered the epic adventures, fierce warrior cats, and thrilling fantasy world of the mega-bestselling Warriors series. This stand-alone entry is perfect for new readers and dedicated fans alike.



     

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  • EL ROBOT COMPLETO (SAGA DE LOS ROBOTS 1) de ISAAC ASIMOV

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    • EL ROBOT COMPLETO (SAGA DE LOS ROBOTS 1)
    • ISAAC ASIMOV
    • Número de páginas: 504
    • Idioma: CASTELLANO
    • Formatos: Pdf, ePub, MOBI, FB2
    • ISBN: 9788498891256
    • Editorial: ALAMUT EDICIONES
    • Año de edición: 2019

     

     

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    Las historias sobre robots de Asimov reunidas en una colección definitiva. Las Tres Leyes de la Robótica 1. Un robot no debe dañar a ningún ser humano ni, por inacción, permitir que un ser humano sufra daño 2. Un robot debe obedecer las órdenes que le sean dadas por un ser humano, salvo cuando dichas órdenes contravengan la Primera Ley 3. Un robot debe proteger su propia existencia, siempre y cuando dicha protección no contravenga ni la Primera ni la Segunda Ley En El robot completo se recopilan los relatos de robots positrónicos, posiblemente la creación más celebrada de la prodigiosa imaginación de Isaac Asimov, ordenados temáticamente por el propio autor. Desde los primeros modelos no humanoides hasta la paradójica complejidad de los robots que desean ser humanos, pasando por los intrincados recovecos de comportamiento robótico inducido por las Tres Leyes, e incluyendo los famosos relatos de Yo, robot, así como los protagonizados por la sagaz robopsicóloga Susan Calvin.

     

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